PubMed
Permanent URI for this collectionhttps://acikarsiv.thk.edu.tr/handle/123456789/2549
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Publication A numerical study on indentation properties of cortical bone tissue: influence of anisotropy(2015) Demiral M; Demiral M, Abdel-Wahab A, Silberschmidt V.Publication Elasticity-based mechanism for the collective motion of self-propelled particles with springlike interactions: a model system for natural and artificial swarms(2013) Ferrante E; Ferrante E, Turgut AE, Dorigo M, Huepe C.Publication Comparison of Two Different Distraction Methods Affecting the Level of Pain and Anxiety during Extracorporeal Shock Wave Lithotripsy: A Randomized Controlled Trial(2018) Gezginci E; Gezginci E, Iyigun E, Yalcin S, Bedir S, Ozgok IY.Publication Numerical flow analysis of coronary arteries through concentric and eccentric stenosed geometries(2013) Melih Guleren K; Melih Guleren K.Publication Effect of glottic geometry on breathing: three-dimensional unsteady numerical simulation of respiration in a case with congenital glottic web(2016) Gökcan MK; Gökcan MK, Günaydinoðlu E, Kurtuluþ DF.Publication A novel method for retinal optic disc detection using bat meta-heuristic algorithm(2018) Abdullah AS; Abdullah AS, Özok YE, Rahebi J.Publication Observation of Mode Splitting in Photoluminescence of Individual Plasmonic Nanoparticles Strongly Coupled to Molecular Excitons(2017) Wersäll M; Wersäll M, Cuadra J, Antosiewicz TJ, Balci S, Shegai T.Publication Publication A comparison of peptide amphiphile nanofiber macromolecular assembly strategies(SPRINGER, 2019) Dana, Aykutlu; Tekinay, Ayse B.; Tekin, E. Deniz; Tekin, Emine Deniz; Stanford University; Turk Hava Kurumu University; Turkish Aeronautical Association.Supramolecular peptide nanofibers that are composed of peptide amphiphile molecules have been widely used for many purposes from biomedical applications to energy conversion. The self-assembly mechanisms of these peptide nanofibers also provide convenient models for understanding the self-assembly mechanisms of various biological supramolecular systems; however, the current theoretical models that explain these mechanisms do not sufficiently explain the experimental results. In this study, we present a new way of modeling these nanofibers that better fits with the experimental data. Molecular dynamics simulations were applied to create model fibers using two different layer models and two different tilt angles. Strikingly, the fibers which were modeled to be tilting the peptide amphiphile molecules and/or tilting the plane were found to be more stable and consistent with the experiments.Publication Alkaline Phosphatase-Mimicking Peptide Nanofibers for Osteogenic Differentiation(AMER CHEMICAL SOC, 2015) Gulseren, Gulcihan; Yasa, I. Ceren; Ustahuseyin, Oya; Tekin, E. Deniz; Tekinay, Ayse B.; Guler, Mustafa O.; Tekin, Emine Deniz; Ihsan Dogramaci Bilkent University; Turk Hava Kurumu University; Turkish Aeronautical AssociationRecognition of molecules and regulation of extracellular matrix synthesis are some of the functions of enzymes in addition to their catalytic activity. While a diverse array of enzyme-like materials have been developed, these efforts have largely been confined to the imitation of the chemical structure and catalytic activity of the enzymes, and it is unclear whether enzyme-mimetic molecules can also be used to replicate the matrix-regulatory roles ordinarily performed by natural enzymes. Self-assembled peptide nanofibers can provide multifunctional enzyme-mimetic properties, as the active sequences of the target enzymes can be directly incorporated into the peptides. Here, we report enhanced bone regeneration efficiency through peptide nanofibers carrying both catalytic and matrix-regulatory functions of alkaline phosphatase, a versatile enzyme that plays a critical role in bone formation by regulating phosphate homeostasis and calcifiable bone matrix formation. Histidine presenting peptide nanostructures were developed to function as phosphatases. These molecules are able to catalyze phosphate hydrolysis and serve as bone-like nodule inducing scaffolds. Alkaline phosphatase-like peptide nanofibers enabled osteogenesis for both osteoblast-like and mesenchymal cell lines.